Born in London to Irish immigrant parents, Anne-Marie Duff didn't consider acting until her mid-teens. She attended London's Drama Centre, which helped her cultivate a career on the stage, appearing in "King Lear" and "War and Peace" while still a student. Duff's first big break came when she was cast as eldest child Fiona McBride on somewhat controversial British sitcom "Shameless" (Channel 4 2004-13). She landed an even bigger role portraying Queen Elizabeth I in the lavish television drama "The Virgin Queen" (BBC 2006). Duff made her way to the big screen in the suburban drama "Notes on a Scandal" (2006), the 1980s period piece "Is Anybody There?" opposite Michael Caine (2008), and the John Lennon biopic "Nowhere Boy" (2009), in which she played the teenage Lennon's estranged mother Julia. In 2013, Duff made her Broadway debut starring in "Macbeth" as Lady MacBeth opposite Ethan Hawke.