Militant forces opposing Syrian President Bashar al-Assad have launched their biggest offensive in years this week, .
Government forces offered little resistance, the war monitor said, and the army admitted that rebels had entered "large parts" of the city.
Here is what is happening in Syria and what it could mean for the Middle East.
Who is the group in control of Aleppo?
Hayat Tahrir al-Sham (HTS) is a jihadist alliance led by Al-Qaeda's former Syria branch. With allied factions, the group attacked government-held areas of the northern province of Aleppo and the northwestern Idlib region on 25 November.
HTS is proscribed as a terrorist organisation by the Canadian, United Kingdom and Australian governments.
The Britain-based Syrian Observatory for Human Rights war monitor said the militants had seized dozens of towns and villages in the north and "took control of most of" Aleppo.
The violence has killed at least 327 people, mostly combatants on both sides, but also including at least 44 civilians, said the Observatory, which relies on a network of sources inside Syria.
Dareen Khalifa, a researcher at the International Crisis Group think tank, said the rebels had prepared months for this offensive.
"They've framed it as a defensive move against regime escalation," Khalifa said, as Syrian government and Russian strikes on the area intensified leading up to the attack.
But HTS and their allies are "also looking at the broader regional and geostrategic shift", she said.
Why is the timing important?
The rebels, working in a joint operations room, launched their attack the same day a .
During more than 13 months of hostilities, Israel also intensified attacks on Iran-backed groups in Syria including Hezbollah, which for years has fought on the side of the Syrian government in the country's civil conflict.
Along with Iran, Russia is also a close ally of Assad. Its intervention in Syria's civil war in 2015 turned the momentum of the conflict in favour of Damascus.
"They're thinking this is a time when the Iranians are weakened, when the regime is cornered and when Turkey is emboldened vis-a-vis Russia," Khalifa said.
Turkey has positioned itself as a possible mediator in the Ukraine war and is a key trade and finance centre for Western-sanctioned Russia.
Opposition forces in an area outside Aleppo. Source: AAP, AP / Ghaith Alsayed
What major powers are at play?
The main powers backing each side of the conflict have so far refrained from making escalatory remarks.
The Kremlin on Friday said it hoped Syria would quickly "restore order" in Aleppo, while Iran has blamed the offensive on an American-Israeli plot to destabilise the region.
Turkey has demanded an end to "attacks" on the rebel enclave of Idlib in Syria, where Syrian and Russian warplanes launched air strikes.
"In the next few days, if (rebels) can sustain their gains it will be a test to whether or not Turkey will go all-in," Khalifa said.
Opposition forces took control of areas outside Aleppo, Syria, this week. Source: AAP / Ghaith Alsayed/AP
Turkish forces and Turkey-backed rebel factions control swathes of northern Syria.
Turkey initially sought to topple Assad after the Syrian conflict erupted in 2011, but as government forces regained territory, Turkish President Recep Tayyip Erdogan reversed course.
In a post on X, Caroline Rose, of the Washington-based New Lines Institute, said the Aleppo offensive appears to be "a way to force the regime to negotiate with a weakened hand".
What about the Assad government?
The Syrian government has reeled from its biggest loss of territory in years this week.
"Regime lines have crumbled at an incredible pace that has taken everyone by surprise," Khalifa said.
The rebels also cut off the Damascus-Aleppo M5 highway, in addition to controlling the strategic M5-M4 junction that also connects Syria's second city to regime stronghold Latakia, on the Mediterranean coast.
Rami Abdel Rahman, who heads the Syrian Observatory for Human Rights, said the rebels advanced into Aleppo "without any significant pushback from regime forces".
"It is strange to see regime forces being dealt such big blows despite Russian air cover and early signs that HTS was going to launch this operation," Abdel Rahman said.
Syria has largely relied on Russian air power and Hezbollah fighters on the ground to regain swathes of the country lost to rebels early in the war.
But the Iran-backed Hezbollah has taken heavy losses in its war with Israel.
Meanwhile, "Russia's presence has thinned out considerably and quick reaction air strikes have limited utility", said Aaron Stein, president of the US-based Foreign Policy Research Institute.
Speedy rebel advances are "a reminder of how weak the regime is and, perhaps, how they have grown complacent in the last couple of years" as battles wound down, he said.
