Pence was at Cape Canaveral in Florida Thursday for a speech to employees and also took a tour.
At one point Pence was guided to piece of gear with a sign that identified it as "critical space flight hardware" and a warning in bright, red capital letters: do not touch.
Pence placed his left palm flat on it, anyway, as cameras clicked away. One of the people in the picture is Florida Senator Marco Rubio.
The rest is meme and tweet history.
Pence sent out a tweet Friday in which he said he was sorry -- a blurb with a President Donald Trump-esque exclamation point at the end -- and joked that he, Pence, was not really to blame for ignoring the sign, which his hand almost touches.
"Sorry @NASA ... @MarcoRubio dared me to do it!," Pence wrote.
NASA put out a tweet saying it was no big deal, that the hardware -- a big piece of metal roughly the shape of a nuclear reactor cooling tower and part of a spacecraft-in-the-making called the Orion -- needed to be cleaned, anyway.
Pence put out another light-hearted tweet saying it was the not the first this happened: it featured his photo of NASA ignominy but with a porcupine -- not the space gear -- graced by his hand.
Of course, the original photo went viral and many social media users were scathing in their criticism of Pence. Pence supporters said the former were making a big deal out of nothing.
"Good to know our vice president has the self control of a sugar charged 3rd grader on a field trip," wrote someone with the handle @KentoTFH.
"Again administration blaming someone else," wrote @PatStevens2, referring to Pence's fingering of Rubio.
To wit, some of the things Trump has blamed others for: Barack Obama for not acting more forcefully against Russia's election meddling, which Trump has even not fully acknowledged; "the generals" who he said ordered a US raid in Yemen in February in which a US Navy SEAL was killed.
In the NASA flap, others recalled Pence's reputation as being famously straight-laced and conservative, to the point where he has said he would never dine alone with a woman who is not his wife.
"This is an example of why you don't eat with women, correct?," wrote @squidlace.
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