Jill Soloway, who was honoured for comedy directing at the ceremony in Los Angeles, described the Republican presidential candidate as "the most dangerous monster to ever approach our lifetimes".
Speaking backstage, she told reporters: "Jews were otherised in Nazi Germany to gain political power for Hitler. Right now Donald Trump is doing the same thing. He's otherising people.
"He calls women pigs if they don't look like beauty pageant contestants. He blames Muslims and Mexicans for our problems. He makes fun of disabled people.
"This is otherising with a capital O. It has been used in our history before to start and win wars.
"He needs to be called out at every chance ... for being one of the most dangerous monsters to ever approach our lifetimes.
"He's a complete dangerous monster and any moment that I have to call him out for being an inheritor to Hitler I will."