A carer for disabled Adelaide woman Ann Marie Smith has been charged with manslaughter over the 54-year-old's death.
Ms Smith, who lived with cerebral palsy, died in hospital in April from septic shock, multiple organ failure, severe pressure sores and malnourishment while under the care of the National Disability Insurance Scheme.
Detective Superintendent Des Bray said it was alleged she died of serious criminal neglect and her death was preventable.
He said police had conducted a comprehensive investigation looking at all aspects of her care.
"We have built a picture of Annie's life since the death of her parents in 2009," Det Supt Bray said.
"She led an active and outgoing life from 2009 to 2018 but in the past two years she became more socially isolated and her quality of life deteriorated."
Police launched their investigation soon after Ms Smith's death while the NDIS commissioner also appointed former Federal Court judge Alan Robertson to lead an independent inquiry.
Detectives said Ms Smith had been spending her days and sleeping at night in the same woven cane chair with extremely poor personal hygiene and no nutritional food.
Detectives on Thursday charged a 68-year-old woman with her manslaughter.
She is expected to appear in Adelaide Magistrates Court on Thursday or Friday.
