"Those who deny it (climate change) should go to the scientists and ask them. They are very clear, very precise," the pontiff said Monday during a press conference on the return leg of a five-day Colombia trip.
"A phrase from the Old Testament comes to mind: 'man is stupid, a stubborn, blind man'," he added.
Francis said individuals and politicians had a "moral responsibility" to act on advice from scientists, who had clearly outlined what must be done to halt the course of global warming.
"These aren't opinions pulled out of thin air. They are very clear," he said.
"They (world leaders) decide and history will judge those decisions," he added.
The pope has been an ardent supporter of efforts to combat climate change and its consequences to the world's most vulnerable populations, in terms of pollution, disease, wars and migration.
He has regularly criticised politicians in comments seen by many as a swipe at President Donald Trump's decision to pull the United States out of the COP21 Paris Agreement which binds countries to national pledges to reduce greenhouse gas emissions.
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Pope Francis said he hopes US President Donald Trump will "reconsider" his decision to end an amnesty for hundreds of thousands of people brought illegally to the country as children.
"Removing young people from their families is not going to have a positive effect on either the youngsters or their families," the pontiff said during a press conference on the return leg of a five-day Colombia trip.
Francis said he knew of Trump's decision last week to abrogate an order issued by his predecessor Barack Obama that protected around 800,000 young people by granting them temporary legal status.
"I don't know how the decision was taken," he said, adding: "I hope he will reconsider".
The move gives the so-called "Dreamers" -- many of them Hispanic who are now in their twenties -- somewhere between six and 24 months before they become illegal and subject to potential deportation.
"I have heard the US president present himself as a pro-life man, and if he is that he will understand the importance of the family, and life, and how the family unit must be defended," Francis said.
Trump's move fulfilled a campaign promise of zero tolerance toward illegal immigrants.
But the president insisted he was showing compassion for the Dreamers, many of whom know only the United States and speak only English, by giving Congress six months to craft a lasting legal solution.
